From Nilay Patel's Samsung Galaxy Note 10.1 review:
On paper, the Note 10.1 seems extremely capable of creating that world: it has an extremely fast quad-core processor, the ability to run multiple apps side-by-side on the 10.1-inch display, and, of course, Samsung’s Wacom-powered S Pen stylus, which has been upgraded from the smartphone Note to offer 1024 levels of pressure sensitivity. Other Android devices have tried and failed to meaningfully incorporate stylus support, but only Samsung’s 5-inch Galaxy Note smartphone has ever been a success, and I had high hopes the Note 10.1 would simply be a larger version of that experience.
It’s pretty clear that people want their tablets to support pen input — the huge market of iPad styluses is proof positive of that. Samsung’s S Pen system is way ahead of the curve in that regard: it’s responsive, it’s precise, and it works well enough, most of the time.
But a pretty good pen system built on top of a disappointing Android tablet still makes for a disappointing Android tablet. There’s just no reason to suffer through it: the Nexus 7 costs less than half as much as the Note and is without question the best Android tablet available. The iPad costs the same $499 and offers an unrivaled selection of apps, an industry-leading display, and so many stylus accessories and note-taking tools that you won’t even remember that the S Pen makes them all look a bit primitive. And a regular notebook and pen do not make blooping sounds at the slightest provocation.